Cell-free skin graft heals chronic leg ulcers
10 May 2013
A new type of skin graft produced by NHS Blood and Transplant (NHSBT) Tissue Services has healed the chronic leg ulcers of more than half of patients involved in the first trial.
The new product, known as dCELL Human Dermis, is made from skin donated by deceased tissue donors and processed to remove all the donor cells using Tissue Regenix’ dCELL technology.
The product is not rejected by the patients’ immune system. It maintains the essential structure of normal skin and serves as an ideal scaffold for the patients’ cells to migrate into and regenerate living, functional skin tissue.
Lower limb ulcers, which are often secondary to other conditions
such as poor circulation and diabetes, are a common age-related
condition which is increasing in frequency with an aging and
increasingly unfit population.
“Care and treatment of chronic leg ulcers is estimated to consume 1% of the NHS total budget¹. Our research and development of a treatment that can heal these wounds may lead to better use of NHS resources and greatly improve patients’ quality of life.”
Antony Odell, Managing Director Tissue Regenix, said: “This dCELL
Dermis clinical treatment has the potential to help many patients
and address the £400 million annual bill that the NHS pays to treat
chronic wounds of the lower leg. Research firm Kalorama estimates
the global market for chronic and acute wound care could be worth
$21 billion by 2015 (from $16.8 billion in 2012). The successful
trial and development of this NHSBT Dermis treatment is a critical
part of our ongoing plans to commercialise treatments developed
using our dCELL technology.”