New biomaterials can promote regeneration of brain tissue after
injury and disease damage
3 December 2012
Research at the Universitat Politècnica de València has shown
that a biocompatible material implanted in the brain is colonized
within two months by neural cells and irrigated by new blood vessels.
This allows the generation, within these structures, of new neurons and glia, capable of repairing injured brain tissue caused by trauma, stroke
or neurodegenerative disease, among other causes.
The synthetic structures used in this study are made with a
porous and biocompatible polymeric material called acrylate
copolymer. In the first phase of the project, the structures have
been studied in vitro by implanting them into neural tissue, and
subsequently also in vivo, when implanted in two areas of the adult
rat brain: the cerebral cortex and the subventricular zone, the most
important source of generation of adult neural stem cells.
The study has confirmed the high biocompatibility of polymeric
materials, such as acrylate copolymer, with brain tissue and opens
new possibilities of the effectiveness of the implementation of
these structures in the brain, seeking optimum location for
developing regenerative strategies of the central nervous system.
Furthermore, the results are particularly relevant when one
considers that in the adult brain neuroregeneration capacity is more
limited than in younger individuals and that the main impediment for
this is the lack of revascularization of damaged tissue, something
that the biomaterial studied has shown to favour.
Martínez-Ramos C, Vallés-Lluch A, Verdugo JMG, Ribelles JLG,
Barcia JA, Orts AB, López JMS, Pradas MM. 2012. Channeled scaffolds
implanted in adult rat brain. J Biomed Mater Res Part A