New semen test for testicular cancer
25 June 2012
The Rigshospitalet in Copenhagen has found a new and simple
way of detecting testicular cancer before it starts, by looking for
markers in a sperm sample.
Previously, suspicion of testicular cancer meant that a patient had
to be subjected to one or two painful biopsies, and despite a 95%
survival rate, the testicular cancer diagnosis meant having to go
through treatment that could be extremely hard on the body.
"So far, we have lacked knowledge about the markers that can reveal
early stages of testicular cancer. Now we have found these markers,
and we are therefore able to see from a simple sperm sample whether
a patient will develop testicular cancer. In this way, we can
provide treatment for some men who would otherwise not have found
the disease until much later, and we can set in at an earlier stage,
and with a more gentle treatment.
This is beneficial in particular for men with testicular cancer,
because they are usually hit by the disease as early as in their 20s
or 30s, which means they have a long life ahead of them with
possible late complications from their cancer treatment.
Furthermore, we can assume that, in the long run, this means a
better chance of survival for testicular cancer patients," says
Kristian Almstrup from the Department of Growth and Reproduction at
Poor sperm quality can indicate cancer
Men with poor sperm quality, in particular, who consult the hospital
because of fertility problems, are being examined to detect possible
early stages of testicular cancer. According to the researchers,
poor sperm quality and predisposition to testicular cancer can be
traced all the way back to foetal germ-cell development.
"We believe that the basis for testicular cancer occurs as early as
in the foetal stage. Disruptions in foetal development of the
testicles can, if mild, cause reduced sperm quality, or, if severe,
cause precursor cells of testicular cancer. Previously, we had to
perform a biopsy to detect these precursors, which today we can
detect by merely analysing a sperm sample," says Kristian Almstrup.
Experience shared in Europe
The research team, which in addition to Senior Researcher Kristian
Almstrup, consists of Prof. Consultant Niels Erik Skakkebæk and Head
of Research Ewa Rajpert-De Meyts has developed a special scanning
microscope and software which can analyse sperm samples. The
discovery has attracted much attention from colleagues abroad.
"So far, we are cooperating with researchers in Norway, Germany and
Poland, who can make use of our discovery in different ways. The
equipment is expensive, so to begin with we are helping by analysing
their samples, but in the long term we would like to join up with a
company that can supply a total kit for use by other researchers and
physicians in different European countries," says Kristian Almstrup.
Experience from international cooperation is good according to the
"We have concentrated extensively on assisting other researchers and
physicians on their own terms. In Norway, for example, a biopsy is
not taken of both testicles, so even if they find cancer in one
testicle, possible cancer in the other testicle is not addressed. In
Germany, they always take two biopsies, just to be safe. Therefore,
we can help both countries in different ways.
"In Norway, we can help by providing them the opportunity to detect
any cancer in the other testicle, without having to take further
biopsies, and in Germany, we can help detect more cases of
testicular cancer in men who only come to have their sperm quality
analysed. We therefore have real good experience from cooperating
with researchers in other countries, instead of just imposing our
way of doing things on them," says Kristian Almstrup.