EU SKINSPECTION project develops hybrid multimodal 3D imaging system
18 April 2012
The EU-funded SKINSPECTION project has developed a novel
multimodal hybrid diagnostic imaging system with the capability to
perform non-invasive high resolution three-dimensional imaging in-vivo.
The SKINSPECTION approach combines two-photon imaging with
time-correlated single photon detection, autofluorescence lifetime
imaging, high-frequency ultrasound and optoacoustic imaging.
The innovative combination of these modalities allows to obtain a
wide-field view with quantitative depth information of skin lesions
and a close-look into particular intra-tissue compartments with
quantitative hyperspectral information and subcellular resolution.
The goal of the project is to provide a novel unique tool for
early diagnosis and treatment control of skin cancer and skin
disease. For achieving this objective, two systems for microscopic
and macroscopic imaging of lesions were developed in the last three
years by the project partners JenLab GmbH and Imperial College
London (two-photon microscopy/FLIM) and Fraunhofer IBMT (Fraunhofer
Institute for Biomedical Engineering) and kibero GmbH (optoacoustic/ultrasound
The systems were successfully certified for clinical studies and
are currently being evaluated for imaging of skin lesions in a
bicentric clinical trial at Hammersmith Hospital, London and
Universita di Modena.