Biotage announces new methods for extraction of key compounds
14 Feb 2011
Biotage (STO: BIOT), a supplier of tools and technology for
analytical and medicinal chemistry, has introduced a new series of
application notes utilizing the industry-standard RapidTrace SPE
New applications include extractions from plasma, urine and whole
blood, typically assayed in clinical and forensic protocols.
Additionally, a new soil analysis method for dioxins and furans
joins the presently available EPH protocols from Biotage.
“By offering SPE methods ready for use on the RapidTrace, labs
are better able to quickly achieve consistent solid phase extraction
results that meet industry needs for low to high throughput
applications,” says Anna-Karin Wihlborg, Biotage Product Manager.
“These new methods further strengthen our portfolio of support
illustrate that Biotage is committed to providing the tools our
customers need to achieve greater results.”
The RapidTrace Workstation is the gold standard for efficient and
reliable solid phase extraction from low to high throughput
applications. Up to 10 RapidTrace Modules can be controlled
simultaneously by one computer allowing for a scalable solution.
RapidTrace users can receive free software updates with the new
methods pre-loaded by contacting a Biotage Representative. The
RapidTrace utilizes effortless point-and-click software allowing for
simple execution of pre-loaded methods as well as easy custom method
set-up and editing.
Newly released methods for RapidTrace:
- Extraction of Vitamin D from plasma using ISOLUTE: this
method allows extraction of the main active Vitamin D
metabolites; 25-hydroxy-vitamin D and 1α, 25-dihydroxy-vitamin
D. Deficiency can result in various disorders including
osteoporosis, liver and kidney problems to increased risk of
various cancers and multiple sclerosis, making this compound
extremely clinically relevant.
- Extraction of the cocaine metabolite, benzoylecgonine from
urine using ISOLUTE HCX: due to short half life of cocaine, the
screening for the presence of cocaine in urine is majorly
accomplished via the major metabolite of cocaine;
benzoylecgonine. It allows a profile of use to be constructed
and can be used to determine how long ago from the time of
testing the cocaine was administered.
- Extraction of tricyclic antidepressants from whole blood
using ISOLUTE HCX columns: except for the use of tricyclic
antidepressants (TCAs) to treat depressive disorders, TCA’s have
been found to have significant efficacy in the treatment of
sleep disorders, ADHD, IBS and pain management.
- Extraction of basic drugs of abuse from biological fluids
using ISOLUTE HCX: the typical range of drugs screened using
this generic method are Cocaine, D3 -Cocaine, benzoylecgonine-TMS,
D3-Benzoylegonine-TMS, Amphetamine, D5-Amphetamine,
methamphetamine, codeine, morphine, amitriptyline HCL,
nortriptyline HCL, imipramine HCL, desipramine HCL. These drugs
represent a panel of the most significantly abused drugs as
recommended by The National Institute on Drug Abuse (NIDA).
- Extraction of cyclosporine from whole blood using ISOLUTE
columns: cyclosporine is an immunosuppressant used in organ
transplants to overcome rejection. Subsequent to an organ
transplant, patients are tested at regular intervals for the
presence of very low levels of the compound.
- Extraction of environmental contaminants including dioxins
and furans from soil and sediment samples using ISOLUTE NH2:
dioxins and furans are a family of toxic chemicals. The levels
of these chemicals in air, water and soil are constantly
monitored through screening according to EPA guidelines, typical
detection limits for these compounds in soil and sediments are
0.1 -1.0 parts per billion.
- Extraction of the opiates, morphine and codeine from urine
using ISOLUTE HCX: morphine and codeine are two of the opiates
analyzed in drugs of abuse testing, they are both on the SAMHSA
(Substance Abuse Mental Health Service Administration) lists as
drugs to be tested for workplace drug testing.