Clontech Laboratories and TET Systems extend gene expression systems
11 August 2010
Clontech Laboratories, Inc., a wholly-owned subsidiary of
Takara Bio Inc., and TET Systems (TET), a privately-held German biotech
company based in Heidelberg, have signed an amendment to their existing
license agreement for gene expression systems.
Under the expanded license agreement, Clontech obtains rights to
develop, manufacture and commercialize novel Tet Systems products
such as the Tet-On 3G Inducible Expression System.
The Tet-On 3G Inducible Expression System provides highly
inducible, sensitive control of gene expression. It includes two
novel components, the rights to which were acquired by TET in 2009:
an improved transcriptional activator developed by scientists at the
Academic Medical Center at the University of Amsterdam (AMC) in the
Netherlands, and a novel minimal Tet promoter developed at the
University of Heidelberg in Germany.
The Tet-System currently marketed by Clontech is already the gold
standard for regulated gene expression, as measured by more than
7,000 peer-reviewed scientific publications. The new Tet-On 3G
Inducible Expression System offers researchers even greater control
of gene regulation due to lower expression in the non-induced state,
even in transient transfection settings. The system’s ten-fold
increased sensitivity for the inducing agent (Doxycycline) will also
expand the long-established benefits of dynamic transactivation,
particularly for in vivo models.
Carol Lou, General Manager of Clontech Laboratories, Inc.,
comments: “Clontech has a long history of leadership in developing
technologies for gene delivery and expression, and a long-standing
partnership with TET Systems. We are pleased to continue and extend
this history by adding the Tet-On 3G Inducible Expression System to
our portfolio of Tet System Products, which also includes our
inducible Lenti-X systems.”
Clontech launched a broad suite of Tet-On 3G Inducible Expression
Systems, including different promoters, fluorescent markers, and
bicistronic systems earlier this month.