Lilly, Merck, and Pfizer co-operate to accelerate cancer research in Asia

23 February 2010

Eli Lilly and Company, Merck and Pfizer Inc. have announced the formation of the Asian Cancer Research Group, Inc., (ACRG), an independent, not-for-profit company established to accelerate research and ultimately improve treatment for patients affected with the most commonly-diagnosed cancers in Asia.

The goal of the ACRG is to improve the knowledge of cancers prevalent in Asia and to accelerate drug discovery efforts by freely sharing the resulting data with the scientific community.

The ACRG’s formation represents a prime example of a growing trend in pre-competitive collaboration in which large pharmaceutical companies combine their resources and expertise to rapidly increase knowledge of disease and disease processes.

“Through its work and the subsequent sharing of information, the ACRG hopes to empower researchers, foster innovation and improve the prognosis and treatment of patients with cancer,” said Gary Gilliland, M.D., Ph.D., senior vice president and franchise head, Oncology, Merck Research Laboratories.

Initially, the ACRG will focus on lung and gastric cancers, two of the most common forms of cancer in Asia. As many as 40 percent of patients with lung cancer in Asia demonstrate a mutation that is relatively rare in Western patients (EGFR mutation) [1]. This mutation has resulted in differences in response to some types of agents, suggesting that a different research approach is needed for developing treatments for certain patient populations.

Gastric cancer has reached near epidemic proportions in some countries in Asia. Despite its relatively low incidence in the West, gastric cancer is the second largest cause of cancer death in the world, killing more than 630,000 patients per year, more people than all cancers combined in the United States [2].

“Environmental and genetic factors are believed to underlie the dramatic differences in the molecular subtypes and incidence of cancers in Asia and other parts of the world,” said Neil Gibson, Ph.D., chief scientific officer of Pfizer’s Oncology Research Unit. “Although some progress has been achieved in the last few years in understanding and treating these cancers, they remain a huge unmet need and a disproportionate health burden to Asian patients.”

Over the next two years, Lilly, Merck and Pfizer have committed to create one of the most extensive pharmacogenomic cancer databases known to date. This database will be composed of data from approximately 2,000 tissue samples from patients with lung and gastric cancer that will be made publicly available to researchers and, over time, further populated with clinical data from a longitudinal analysis of patients. Comparison of the contrasting genomic signatures of these cancers could inform new approaches to treatment.

Today’s announcement marks the formation of the ACRG. The company is currently focused on establishing collaborative relationships throughout Asia to collect the tissue samples and data. All tissue samples and data will be collected and shared in accordance with good medical practices and local laws.

Lilly has assumed responsibility for ultimately providing the data to the research public through an open-source concept managed by Lilly’s Singapore research site. Moreover, Lilly, Merck and Pfizer will each provide technical and intellectual expertise.

“The ACRG is about sharing information for the common good,” said Kerry Blanchard, M.D., Ph.D., vice president and leader of drug development in China for Lilly and who represented Lilly in the ACRG’s formation. “This company will aid researchers around the world to develop diagnostics, tailor current treatments and develop novel therapies to improve outcomes for affected patients with lung, gastric and perhaps other forms of cancer.”

References

1. Herbst, RS et al., (2008). N Engl J Med 359, 13, 1367-1380

2. Parkin, DM et al., (2005). CA Cancer J Clin 55, 2, 74-108.