Metabolic surgery could revolutionize diabetes treatment
28 May 2009
Metabolic surgery, a new surgical approach to metabolic disease, may
provide the key to curing diabetes in some patients, according to a
paper presented at the American Association of Clinical Endocrinologists
(AACE) 18th Annual Meeting & Clinical Congress.
"This goes beyond just weight-loss surgery," Chief of
Gastrointestinal Metabolic Surgery at Weill Cornell Medical College
Francesco Rubino, MD, said. "For its clinical potential, and maybe even
more for its implications for the understanding of diabetes, metabolic
surgery is one of the most important research opportunities for the next
decade in medicine."
According to Dr Rubino, a growing body of evidence suggests that the
mechanisms of diabetes resolution after surgery involve intestinal
signals: "I am confident that we may see important discoveries occur as
we direct our attention to the role of the bowel in diabetes."
Recent studies have indicated that bariatric surgery, an approach
typically used to treat severe obesity, often results in normalization
of blood sugar levels and other metabolic abnormalities. This results in
a reduction of the overall risk of mortality associated with diabetes in
severely obese patients.
Dr Rubino's personal research showed for the first time that the
effects of bariatric surgery on diabetes cannot be entirely explained by
weight loss, and are intrinsic with the change of intestinal anatomy
characteristic of these procedures. As a result, experts have been
studying the biological impacts of the surgery on mechanisms of glycemic
control, and are exploring the possibility to use gastrointestinal
surgery to treat diabetes per se.
"It would be premature at this point to argue every diabetes patient
is a candidate for gastrointestinal surgery," Dr Rubino said. "However,
there is enough evidence that surgery should be considered as an option
to endocrinologists in the treatment of type 2 diabetes."
Metabolic surgery is the result of a collaborative effort between
endocrinologists and surgeons working to optimize the surgery for
diabetes patients. Together they can formulate a "tailored
intervention," designing procedures that allow them to gain a greater
understanding of how the disease works.
"Recognizing the need to work as a team across disciplines that
includes endocrinologists and surgeons is the first critical step to
address the issues and opportunities that surgery offers to diabetes
care and research," Dr Rubino said.
Thus far the results are intriguing: "This collaborative effort is
helping us gain a broader, more comprehensive understanding of
diabetes," Rubino said. "In the end it will pay dividends for patients."
For more information about diabetes, download the American College of
Endocrinology's (ACE) Power of Prevention magazine. The
magazine features medical information on prediabetes, type 1 and type 2
diabetes, diabetes complications, and tips on how diabetes patients can
best prepare for disaster.
1. American Association of Clinical Endocrinologists:
2. Power of Prevention magazine:
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