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Microbial Pathogenomics
Publisher: S Karger AG Publication type: Book (Hardback) Pages: 214 Publication date: Aug 2009 A global view of key aspects and future trends These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and Mycobacterium tuberculosis which are human-specific and highly persistent; further bacteria discussed include Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and Staphylococcus. Microbial Pathogenomics provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers. Buy this book
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